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All round, the development of live bacterial vectors for vaccination and anti-tumor therapies is actually a swiftly growing analysis area with much opportunity. The future is dazzling for vectored vaccines.
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Figure three represents the method with the delivery of the foreign gene. A number of invasive bacterial species are shown to productively transfer a eukaryotic expression plasmid into mammalian cells, like S
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carrying HPV-17 E7 fused to a fragment of listerolysin O) was evaluated inside of a Phase I Scientific Demo in patients with metastatic cervical cancer [seventy eight]. This constituted the very first scientific demo using a live attenuated L. monocytogenes;
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